CANAL-U

Statut

Chargé de recherches INSERM

Diplômes

DEA de Biologie Cellulaire et Moléculaire et Sciences de la Santé, 1ère session 1988, mention B (classé 1er).
Thèse d'université, Université de Rennes I, 1993, Mention Très Honorable avec félicitations du Jury.

Parcours

INSERM U 49, Rennes, (Dir. Dr A. Guillouzo):
- DEA, 1987-1988
- Thèse d'université, 1988-1993. Directeur de thèse: Dr. C. Guguen-Guillouzo.
Tumor Cell Biology Department, St Jude Research Hospital, Memphis, USA:
Stage postdoctoral, dans le laboratoire du Dr V. Kidd, janvier 1994 à mars 1996.
INSERM U 49, Rennes, (Dir. Dr A. Guillouzo):
Intégration INSERM au poste de CR2, décembre 1995 (recrutement au concours 1995).
INSERM U 522 (recréée en janvier 1999 à partir de l'unité 49), Rennes, (Dir. Dr C. Guguen-Guillouzo): Promotion INSERM au poste de CR1, janvier 2000.

Prix

Bourse de voyage de "l'American Association for the study for the Liver Diseases" (AASLD), conférence: Liver Regeneration, juin 1993, Airlie Virginie USA.
Bourse postdoctorale du St Jude Research Hospital, 1994-1996, Memphis Tennessee, USA.
Lauréat 1994 du prix Drieux-Chollet de l'Académie Nationale de Médecine, Paris.

Statut

Chercheur CNRS

Parcours

1962-67 Assistant TP (laboratoire de Biologie Cellulaire, J A Thomas)
1968            Entrée au CNRS (laboratoire de Physiologie et immunologie cellulaire
1975            Thèse d'état
1981-83 Institut du Cancer (Montréal) laboratoire de René Simard
depuis 1986 Direction du Laboratoire de Ciné Micro INSERM

Prix

1961 Prix de laFondation de la Vocation (Cinéma Scientifique)

Statut

Directeur de Recherches CNRS

Parcours

1963-1968 - Enseignant/chercheur, département de Chimie, Biochimie et Toxicologie, Ecole Vétérinaire, Kosice, Tchécoslovaquie.
1968-1970 - Research assistant dans le Groupe de Biochimie des stéroïdes du Courtauld Inst. Biochem., Middlesex Hosp. Med. School, Londres.
1970-1985 - Chercheur dans le Lab. Hormones (INSERM U33); intégré au CNRS en 1972.
1980/1981 - 6 mois au MIT, Cambridge (laboratoire de P.A. Sharp).
1981 - 6 mois à l'Université de Louisville (Kentucky, laboratoire de J.L Wittliff).
1983/1985 - 1 année au NKI (Centre Néerlandais de la Recherche sur le Cancer), Amsterdam, Pays-Bas (laboratoire de R. Nusse).

Spécialités

Ingénieur en chimie (spécialité chimie nucléaire); université Technologique, Prague, 1961.
Docteur-ès Sciences, Université Paris VI, 1978.
Responsable d'équipe dans l'Unité de recherches sur les peptides neurodigestifs et le diabète (INSERM U55), puis "Signalisation et fonctions cellulaires: Applications au diabète et aux cancers digestifs" (INSERM U482).

Particularités

Publications liées au cycle cellulaire
1 - Sabbah M, Courilleau D, Mester J, Redeuilh G. Free in PMC, Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. Proc. Natl. Acad. Sci. US. 1999 Sep. 28;96(20):11217-22.
2 - Lallemand F, Courilleau D, Buquet-Fagot C, Atfi A, Montagne MN, Mester J. Sodium butyrate induces G2 arrest in the human breast cancer cells MDA-MB-231 and renders them competent for DNA rereplication. Exp. Cell. Res. 1999 Mar. 15;247(2):432-40.
3 - Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A., Protein, Nucleotide Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics. J. Biol. Chem. 1998 Jun. 12;273(24):14690-7.
4 - Blahovec J, Kostecka Z, Mester J, Cavaille F.[Peptide-like substances in sheep amniotic fluid which regulate proliferation of BP-A31 cells]. Vet. Med. (Praha). 1997 Jul.;42(7):185-9. Slovak.
5 - Buquet-Fagot C, Lallemand F, Montagne MN, Mester J. Related ArticlesEffects of olomoucine, a selective inhibitor of cyclin-dependent kinases, on cell cycle progression in human cancer cell lines. Anticancer Drugs. 1997 Jul.;8(6):623-31.
6 - Gaben AM, Saucier C, Bedin M, Barbu V, Courilleau D, Bon-Hoa DH, Mester J. Activation of p21ras is not sufficient to ensure a complete G1 phase of the cell division cycle in mouse fibroblasts. Oncogene. 1996 Nov. 21;13(10):2113-20.
7 - Louvet C, Djelloul S, Forgue-Lafitte ME, Mester J, Zimber A, Gespach C. Antiproliferative effects of the arotinoid Ro 40-8757 in human gastrointestinal and pancreatic cancer cell lines: combinations with 5-fluorouracil and interferon-alpha. Br. J. Cancer. 1996 Aug.;74(3):394-9.
8 - Joensuu T, Mester J. Inhibition of cell cycle progression by sodium butyrate in normal rat kidney fibroblasts is altered by expression of the adenovirus 5 early 1A gene. Biosci. Rep. 1994 Dec.;14(6):291-300.
9 - Fagot D, Buquet-Fagot C, Lallemand F, Mester J. Antiproliferative effects of sodium butyrate in adriamycin-sensitive and -resistant human cancer cell lines. Anticancer Drugs. 1994 Oct.;5(5):548-56.
10 - Louvet C, Empereur S, Fagot D, Forgue-Lafitte E, Chastre E, Zimber A, Mester J, Gespach C. The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro. Cancer Lett. 1994 Sep. 30;85(1):83-6.
11 - Fagot D, Buquet-Fagot C, Mester J. Mitogenic signaling by prostaglandins in chemically transformed mouse fibroblasts: comparison with phorbol esters and insulin. Endocrinology. 1993 Apr.;132(4):1729-34.
12 - Buquet-Fagot C, Fagot D, Mester J. Cell cycle dependent regulation of cdc2 mRNA in mouse fibroblasts: requirement of protein synthesis and of continued mitogenic stimulation. J. Cell. Physiol. 1993 Apr.;155(1):204-9.
13 - Forgue-Lafitte ME, Coudray AM, Fagot D, Mester J. Related Effects of ketoconazole on the proliferation and cell cycle of human cancer cell lines. Cancer Res. 1992 Dec. 15;52(24):6827-31.
14 - Fagot D, Buquet-Fagot C, Mester J. Antimitogenic effects of dexamethasone in chemically transformed mouse fibroblasts. Endocrinology. 1991 Aug.;129(2):1033-41.
15 - Gaben AM, Mester J. BALB/C mouse 3T3 fibroblasts expressing human estrogen receptor: effect of estradiol on cell growth. Biochem. Biophys. Res. Commun. 1991 May 15;176(3):1473-81.
16 - Gaben-Cogneville AM, Breant B, Coudray AM, Hoa DH, Mester J. Differentiation of newborn rat preadipocytes in culture: effects of insulin and dexamethasone.Exp. Cell. Res. 1990 Nov.;191(1):133-40.
17 - Charollais RH, Buquet C, Mester J. Butyrate blocks the accumulation of CDC2 mRNA in late G1 phase but inhibits both the early and late G1 progression in chemically transformed mouse fibroblasts BP-A31.J Cell. Physiol. 1990 Oct.;145(1):46-52.
18 - Buchou T, Mester J. Fibroblast growth factor-dependent mitogenic signal transduction pathway in chemically transformed mouse fibroblasts is similar to but distinct from that initiated by phorbol esters. J. Cell. Physiol. 1990 Mar.;142(3):559-65.
19 - Forgue-Lafitte ME, Coudray AM, Breant B, Mester J. Proliferation of the human colon carcinoma cell line HT29: autocrine growth and deregulated expression of the c-myc oncogene. Cancer Res. 1989 Dec. 1;49(23):6566-71.
20 - Buchou T, Charollais RH, Fagot D, Mester J. Mitogenic activity of phorbol esters and insulin-like growth factor 1 in chemically transformed mouse fibroblasts BP-A3: independent effects and differential sensitivity to inhibition by 3-isobutyl-1-methyl xanthine. Exp. Cell. Res. 1989 May;182(1):129-43.
21 - Charollais RH, Mester J. Related ArticlesResumption of cell cycle in BALB/c-3T3 fibroblasts arrested by polyamine depletion: relation with "competence" gene expression. J. Cell. Physiol. 1988 Dec.;137(3):559-64.PMID: 3142887; UI: 89054180.
22 - Buchou T, Charollais RH, Mester J. Related Articles Involvement of serum factor(s) adsorbed to the dish in the response of cycloheximide-pretreated BP-A31 cells to serum pulses.Exp Cell Res. 1988 Feb.;174(2):411-20. PMID: 3276538; UI: 88111948.
23 - Mester J, Wagenaar E, Sluyser M, Nusse R. Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice. J. Virol. 1987 Apr.;61(4):1073-8.PMID: 3029401; UI: 87141322.
24 - Gray HE, Buchou T, Mester J. Serum-induced G0/G1 transition in chemically transformed 3T3 cells. Independence of protein synthesis, stable "memory", and enhancement by cycloheximide pretreatment. Exp. Cell. Res. 1987 Mar.;169(1):95-104.PMID: 3545864; UI: 87134038.
25 - Younglai EV, Godeau F, Mester J, Baulieu EE. Increased ornithine decarboxylase activity during meiotic maturation in Xenopus laevis oocytes. Biochem. Biophys. Res. Commun. 1980 Oct. 16;96(3):1274-81.